Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage

نویسندگان

  • Lixia Liu
  • Xiuqin Wu
  • Bingchen Zhang
  • Wei Yang
  • Daliang Li
  • Yanqiu Dong
  • Yujiao Yin
  • Qi Chen
چکیده

Background: The beneficial properties of tea polyphenols have been extensively studied; however, less attention has been paid to their effects, especially anti-inflammatory effect during exhaustive exercise. Objective: The present study assessed the potential protective effects of tea polyphenols against the fatigue, inflammation and tissue injury caused by an exhaustive exercise bout in rats. Design: Twenty-four healthy male rats were divided into three groups. Group C was a sedentary control group, Groups E+TP and Group E performed a single exhaustive swimming test; all groups had normal diets, but Group E+TP was supplemented with tea polyphenols. All rats were immediately euthanized after exhaustive exercise, and biochemical and inflammatory parameters, including lactic acid (LA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), lactic dehydrogenase (LDH), and creatine kinase (CK) activity levels, were measured. Reverse transcription (RT) and Real-Time PCR was employed to evaluate the mRNA expression of IL-1β in the liver. Results: The results showed a decrease in serum LA levels (22%, p < 0.05) in rats that consumed dietary tea polyphenols. Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-α: 13%, p < 0.05; IL-1β: 10%, p < 0.05; and IL-6: 48%, p < 0.05) and shifted the serum IL-10/TNF-α ratio to a predominantly anti-inflammatory milieu (0.52 ± 0.07 vs. 0.67 ± 0.10, p < 0.01). Furthermore, the polyphenols effectively inhibited the release of tissue damage markers (CK: 24%, p < 0.05 and LDH: 28%, p < 0.05) in the serum and decreased IL-1β mRNA expression in the liver. Conclusions: This study indicated that tea polyphenols could significantly protect rats from the fatigue, inflammation and tissue damage induced by acute exhaustive exercise.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

​The Effects of two Weeks Exhaustive swimming and Curcumin Supplementation on Liver Damage Biomarkers Caused by Alcohol Consumption in Male Wistar Rats

Background: Curcumin is an active ingredient in turmeric, which is used as herbal medicine for the treatment of certain diseases. The aim of this study was to investigate the effects of two weeks of exhaustive swimming and supplementation of curcumin on alcohol induced liver damage biomarkers in male wistar rats. Materials and Methods: In this study, 32 male wistar rats were randomly selected ...

متن کامل

Polyphenols in Exercise Performance and Prevention of Exercise-Induced Muscle Damage

Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify dietary strategies or micronutrients able to prevent or at least attenuate the...

متن کامل

P-6: Protective Effects of Green Tea Extract on Lead-induced Damage in Mouse Testis

Background: Lead is a heavy metal that has been known for its adverse effects on many body organs and systems and. In the present study, the protective effect of green tea (GTE) on the male reproductive system following the administration of lead (pb) was investigated. Materials and Methods: Forty male NMRI mice were divided into four groups of 10 animals each. Controls, GTE treated, pb treated...

متن کامل

Chinese green tea consumption reduces oxidative stress, inflammation and tissues damage in smoke exposed rats

Objective(s):One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-in...

متن کامل

The effect of taking green tea extract for 12 weeks on telomerase enzyme content in heart tissue of old rats in response to acute exhaustive exercise

Background & Aims: The prevalence, incidence, and complications of heart disease increase with age. Green tea is an antioxidant which can prevent cellular senescence and cardiovascular diseases. Telomerase enzyme decreases with aging. Acute exhaustive exercise results in disturbances in the oxidative system and production of active oxygen species in the heart tissue. Thus, the present study aim...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 61  شماره 

صفحات  -

تاریخ انتشار 2017